To Phenotype? Or Genotype?…
That is the Question


What is resistance testing?

Resistance Testing refers to two new types of tests that are being used by a number of researchers and health-care providers in the search for better ways to treat people infected with HIV/AIDS.

The first one called a Genotypic test, examines the HIV taken from a patient, looking for the presence of certain genetic mutations that are known to cause resistance to medications.

A Phenotypic test directly measures the actual sensitivity of a patient’s HIV to certain drugs. To do this, phenotypic tests measure the amount of a particular medication needed to inhibit HIV in a test tube.

How might these tests help me?

It is the hope of doctors, and people living with HIV that using these tests will allow them to make better treatment decisions. For example, knowing what medications you might already be resistant to, could save both time, money, and possibly the heartache of taking a bunch medications that could be destined to fail from the start. This is especially important to someone whose combination therapy may have already failed, or someone who may have been infected with resistant virus.

What are the pros and cons?

Unfortunately these tests are not without fault. They are being done on an experimental basis. They are quite expensive and the data can be hard to interpret.

How can I get more info?

Drop by, or call one of the Women Alive Treatment Advocates. They will be happy to give you more detailed information.

This fact sheet is produced by the Women Alive Treatment Education & Advocacy program in cooperation with the Office of AIDS Programs & Policy-Los Angeles County, Department of Health Services.